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The aim of this study was to define the role of the complement factor H (CFH) gene as a predisposing factor for Pemphigus vulgaris (PV) and other autoimmune diseases. Ninety-seven unrelated PV patients and 101 unrelated healthy controls from Turkey participated in the study. The CFH polymorphisms were determined by polymerase chain reaction and Restriction Fragment Length Polymorphism analysis. The frequencies of genotypes and alleles of CFH (rs800292, rs1061170, and rs572545) were compared between PV patients and controls. The genotype and allele frequencies of CFH (rs800292) in PV patients were significantly different from those of controls (pQ:
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